Integration: Our team’s experience across a wide variety of scientific disciplines combined with our unique integrated approach positions Just as a flexible, knowledgeable partner for biotherapeutic research and development.

We offer a suite of biotherapeutic research and development services, leveraging our fully integrated technology platform, J.DESIGN. Clients and collaborators can select specific or integrated services of J.DESIGN, including  J.DISCOVERY™, J.MD™, JP3®, and J.POD®.

J.DISCOVERY™ 

J.DISCOVERY Services – For the identification of superior antibody therapeutics
Featuring AI-derived, hyper-realistic human repertoire; large and diverse humanoid antibody libraries, J.HAL

J.DISCOVERY™ offers complete in vitro and in vivo services, including:    

  • J.HAL – Just Humanoid Antibody Library: antibodies designed and sequence biased in silico for superior developability features. 
    A rapid in vitro selection process for commercial-ready mAbs significantly reduces discovery and development timelines
  • In vivo antibody generation and discovery with a proven and validated platform
  • Fully integrated, end-to-end discovery services: target validation, functional assays, biophysical characterization, post-translational
    modification analysis by mass spec

J.MD™ – Just Molecular Design Services

A suite of research and development services that utilize Abacus™ and other predictive computational tools. Optimizing the design of therapeutic monoclonal antibodies is the most powerful lever for enhancing speed of development and lowering costs. Services include:  

  • Evaluation and engineering of antibody molecules
  • Design of biologically applicable therapeutic modalities from existing active molecules – e.g., fusion proteins or bi-specific immunoglobulins
  • Specific modifications including humanization of antibody therapeutics

JP3® – Just Process & Product Design Services

Leverages high throughput technology to rapidly deliver robust manufacturing processes. Our experienced team of scientists offer research and process development services including:   

  • Stable cell line development and production of clonal cell banks
  • Bioreactor process development – fed batch, intensified fed batch or continuous formats
  • Media development and optimization
  • Purification process development
  • Analytical method development and qualification
  • Bioassay development and qualification for potency, binding, and functional biocharacterization (e.g., ADCC, CDC)
  • High resolution mass spectrometry (Multi-Attribute Method)
  • Formulation development and stability optimization

J.POD® – Just Manufacturing & Plant Design Services

Just’s J.POD® research and development services offer the client unique solutions for the design of flexible, deployable technologies and facilities needed to improve speed and cost-effectiveness of manufacturing, while never compromising quality. J.POD® services are tailored to meet the specific needs of the client, including:

  • Fed batch, intensified fed batch, and continuous process formats
  • GMP cell banking for both master and working cell banks 
  • Drug substance manufacturing for Tox, Phase 1 and Phase 2 clinical trials
  • Unique manufacturing facility design solutions the client can implement
  • Late Phase, Commercial J.POD(R) facility is under construction in Redmond, Washington
  • Expert consulting for a J.POD® designed facility – design phase through regulatory approval, as needed by the client

With decades of industry experience our goal is to utilize all the advanced technology tools our team develops to benefit clients.
– Jim Thomas